Neonatal exposure to citalopram, a serotonin selective reuptake inhibitor, programs a delay in the reflex ontogeny in rats

p.736-740

Detalhes bibliográficos
Autores: Deiró, Tereza Cristina Bomfim de Jesus, Carvalho, Judelita, Nascimento, Elizabeth do, Medeiros, Jaiza Maria Barreto, Cajuhi, Fabiana, Pereira, Kelli Nogueira Ferraz, Castro, Raul Manhães de
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2008
País:Brasil
Recursos:Universidade Federal da Bahia (UFBA)
Repositorio:Repositório Institucional da UFBA
Idioma:inglés
OAI Identifier:oai:repositorio.ufba.br:ri/5852
Acesso em linha:http://www.repositorio.ufba.br/ri/handle/ri/5852
Access Level:acceso abierto
Palavra-chave:Serotonin
Programming
SSRI
Citalopram
Reflex development
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dc.title.pt_BR.fl_str_mv Neonatal exposure to citalopram, a serotonin selective reuptake inhibitor, programs a delay in the reflex ontogeny in rats
dc.title.alternative.pt_BR.fl_str_mv Arq Neuropsiquiatr
title Neonatal exposure to citalopram, a serotonin selective reuptake inhibitor, programs a delay in the reflex ontogeny in rats
spellingShingle Neonatal exposure to citalopram, a serotonin selective reuptake inhibitor, programs a delay in the reflex ontogeny in rats
Deiró, Tereza Cristina Bomfim de Jesus
Serotonin
Programming
SSRI
Citalopram
Reflex development
title_short Neonatal exposure to citalopram, a serotonin selective reuptake inhibitor, programs a delay in the reflex ontogeny in rats
title_full Neonatal exposure to citalopram, a serotonin selective reuptake inhibitor, programs a delay in the reflex ontogeny in rats
title_fullStr Neonatal exposure to citalopram, a serotonin selective reuptake inhibitor, programs a delay in the reflex ontogeny in rats
title_full_unstemmed Neonatal exposure to citalopram, a serotonin selective reuptake inhibitor, programs a delay in the reflex ontogeny in rats
title_sort Neonatal exposure to citalopram, a serotonin selective reuptake inhibitor, programs a delay in the reflex ontogeny in rats
dc.creator.none.fl_str_mv Deiró, Tereza Cristina Bomfim de Jesus
Carvalho, Judelita
Nascimento, Elizabeth do
Medeiros, Jaiza Maria Barreto
Cajuhi, Fabiana
Pereira, Kelli Nogueira Ferraz
Castro, Raul Manhães de
Deiró, Tereza Cristina Bomfim de Jesus
Carvalho, Judelita
Nascimento, Elizabeth do
Medeiros, Jaiza Maria Barreto
Cajuhi, Fabiana
Pereira, Kelli Nogueira Ferraz
Castro, Raul Manhães de
author Deiró, Tereza Cristina Bomfim de Jesus
author_facet Deiró, Tereza Cristina Bomfim de Jesus
Carvalho, Judelita
Nascimento, Elizabeth do
Medeiros, Jaiza Maria Barreto
Cajuhi, Fabiana
Pereira, Kelli Nogueira Ferraz
Castro, Raul Manhães de
author_role author
author2 Carvalho, Judelita
Nascimento, Elizabeth do
Medeiros, Jaiza Maria Barreto
Cajuhi, Fabiana
Pereira, Kelli Nogueira Ferraz
Castro, Raul Manhães de
author2_role author
author
author
author
author
author
dc.subject.por.fl_str_mv Serotonin
Programming
SSRI
Citalopram
Reflex development
topic Serotonin
Programming
SSRI
Citalopram
Reflex development
description p.736-740
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2012-05-14T13:57:54Z
dc.date.available.fl_str_mv 2012-05-14T13:57:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5852
dc.identifier.issn.none.fl_str_mv 0004-282X
dc.identifier.number.pt_BR.fl_str_mv v. 66, n. 3-B
identifier_str_mv 0004-282X
v. 66, n. 3-B
url http://www.repositorio.ufba.br/ri/handle/ri/5852
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Associação Arquivos de Neuro-Psiquiatria Dr. Oswaldo Lange
publisher.none.fl_str_mv Associação Arquivos de Neuro-Psiquiatria Dr. Oswaldo Lange
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0004-282X2008000500025
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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https://repositorio.ufba.br/bitstream/ri/5852/2/license.txt
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spelling 2012-05-14T13:57:54Z2012-05-14T13:57:54Z20080004-282Xhttp://www.repositorio.ufba.br/ri/handle/ri/5852v. 66, n. 3-Bp.736-740Serotonin influences the growth and development of the nervous system, as well as its behavioral manifestations. The possibility exists that increased brain serotonin availability in young animals modulates their neuro-behavioral responses. This study investigated the body weight gain and reflex ontogeny of neonatal rats treated during the suckling period with two doses of citalopram (5 mg, or 10 mg/kg, sc, daily). The time of the appearance of reflexes (palm grasp righting, free-fall righting, vibrissa placing, auditory startle response, negative geotaxis and cliff avoidance) as well as the body weight evolution were recorded. In general, a delay in the time of reflex development and a reduced weight gain were observed in drug-treated animals. These findings suggest that serotoninergic mechanisms play a role in modulating body weight gain and the maturation of most reflex responses during the perinatal period in rats.Submitted by Texeira Ana (atanateixeira@gmail.com) on 2012-05-14T13:57:54Z No. of bitstreams: 1 Deiró, Teresa Cristina Bomfim de Jesus.pdf: 249935 bytes, checksum: b8f1bda71246519bb8c91f167018bae3 (MD5)Made available in DSpace on 2012-05-14T13:57:54Z (GMT). No. of bitstreams: 1 Deiró, Teresa Cristina Bomfim de Jesus.pdf: 249935 bytes, checksum: b8f1bda71246519bb8c91f167018bae3 (MD5) Previous issue date: 2008São PauloAssociação Arquivos de Neuro-Psiquiatria Dr. Oswaldo Langehttp://dx.doi.org/10.1590/S0004-282X2008000500025reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBASerotoninProgrammingSSRICitalopramReflex developmentNeonatal exposure to citalopram, a serotonin selective reuptake inhibitor, programs a delay in the reflex ontogeny in ratsArq Neuropsiquiatrinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessDeiró, Tereza Cristina Bomfim de JesusCarvalho, JudelitaNascimento, Elizabeth doMedeiros, Jaiza Maria BarretoCajuhi, FabianaPereira, Kelli Nogueira FerrazCastro, Raul Manhães deDeiró, Tereza Cristina Bomfim de JesusCarvalho, JudelitaNascimento, Elizabeth doMedeiros, Jaiza Maria BarretoCajuhi, FabianaPereira, Kelli Nogueira FerrazCastro, Raul Manhães deORIGINALDeiró, Teresa Cristina Bomfim de Jesus.pdfDeiró, Teresa Cristina Bomfim de Jesus.pdfapplication/pdf249935https://repositorio.ufba.br/bitstream/ri/5852/1/Deir%c3%b3%2c%20Teresa%20Cristina%20Bomfim%20de%20Jesus.pdfb8f1bda71246519bb8c91f167018bae3MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5852/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTDeiró, Teresa Cristina Bomfim de Jesus.pdf.txtDeiró, Teresa Cristina Bomfim de Jesus.pdf.txtExtracted texttext/plain26115https://repositorio.ufba.br/bitstream/ri/5852/3/Deir%c3%b3%2c%20Teresa%20Cristina%20Bomfim%20de%20Jesus.pdf.txt44d2029961d08f9905b6eba6848905e1MD53ri/58522022-08-08 13:17:52.389oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttps://repositorio.ufba.br/oai/requestrepositorio@ufba.bropendoar:19322022-08-08T16:17:52Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
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