| Sumario: | This study proposes a systematic literature review on the application of Industry 4.0(I4.0) concepts and elements in the production of biomedicines. The term "industry 4.0" refers to the fourth industrial revolution that is currently underway. Among other factors, the central objective is the integration between the real and the virtual world through Cyber Physical Systems (CPS), Internet of Things (IoT) and other technological elements. The systematic review considered publications up to July 2019, without restriction of start date, as being a relatively recent subject. The results show numerous published papers on the topic I4.0, but few focused on the biopharmaceutical industry. Key documents obtained through systematic review are also discussed throughout this article. Most publications on I4.0 applied to the biopharmaceutical field are still localized in specialized journals, probably because of the incipience of the subject. This fact suggests interesting opportunities for new research on the subject in the established scientific bases.
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