Association of CCR5 G59029A and RANTES -28 C/G polymorphisms in patients with chronic periodontitis and/or Type 2 Diabetes Mellitus, in a Southeastern Mexican population
The aim of this study was to determine the association of poly morphisms CCR5G59029A and RANTES -28C/G in chronic periodontitis (CP) and type 2 diabetes mellitus (T2D). A case control study was carried out that included 163 patients with CP and/or T2D. A periodontal examination was done on all poten...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2018 |
| País: | México |
| Institución: | Universidad Autónoma de San Luis Potosí |
| Repositorio: | Redalyc-UASLP |
| OAI Identifier: | oai:redalyc.org:372960175004 |
| Acceso en línea: | https://www.redalyc.org/articulo.oa?id=372960175004 https://www.redalyc.org/journal/3729/372960175004/ https://www.redalyc.org/journal/3729/372960175004/html/ https://www.redalyc.org/journal/3729/372960175004/372960175004.epub https://www.redalyc.org/journal/3729/372960175004/movil |
| Access Level: | acceso abierto |
| Palabra clave: | Medicina RANTES diabetes Polymorphism periodontitis |
| Sumario: | The aim of this study was to determine the association of poly morphisms CCR5G59029A and RANTES -28C/G in chronic periodontitis (CP) and type 2 diabetes mellitus (T2D). A case control study was carried out that included 163 patients with CP and/or T2D. A periodontal examination was done on all potential participants in order to diagnose CP. To confirm the diag nosis of T2D, peripheral blood samples were collected for laboratory analyses (blood glucose and glycosylated hemoglobin). Genotyping was performed by PCRRFLP. The Genotype AA of CCR5 G59029A increased the risk for CP 7.36 times (95% CI = 1.14-78.27, p = 0.03). This genotype’s A allele also increased T2D risk 2.23 times (95% CI = 1.10-4.54, p = 0.02). Genotype CG of RANTES -28 C/G increased CP risk 5.99 times (95% CI = 1.93-18.57, p = 0.002). Its G allele also raised CP risk 4.55 times (95% CI = 1.58-13.04, p = 0.002). In patients suffering both CP and T2D, the CG genotype was associated with the diseases, increasing their risk 4.68fold (95% CI = 1.60-14.03, p = 0.004). Its G allele raised CP and T2D risk 3.8 times (95% CI = 1.35-10.67, p = 0.008). The AA genotype and allele A of G59029A polymorphism of CCR5 gene is a risk factor for CP. The CG genotype and allele G polymorphism RANTES -28 C/G gene are risk factors for CP in the population studied. The CG genotype and G allele polymorphism RANTES -28 C/G showed a strong association and a subse quent risk factor for the coexistence of CP and T2D. |
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